Electric Literature of 68325-15-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 68325-15-5, name is 3-Chloro-4-cyanopyridine. This compound has unique chemical properties. The synthetic route is as follows.
To an ice-cooled solution of 2-methyl-2-(morpholin-4-yl)propan-1 -ol (4.00 g, 25.1 mmol) in THF (12.5 ml) under an argon atmosphere was added NaH 60% dispersion on mineral oil (1 .1 g, 27.4 mmol) slowly portionwise. The reaction mixture was stirred with ice-cooling for 1 h and a solution of 3-chloropyridine-4-carbonitrile (4.10 g, 29.6 mmol) in THF (64.5 ml) was added. The reaction was allowed to warm slowly to RT and stirred at this temperature for 16h. The reaction was then heated under reflux conditions for 2h. The reaction mixture was quenched with a sat. NH4CI solution and extracted with EtOAc. The organics were combined and washed with sat. NaCI, filtered through a hydrophobic filter and concentrated. The residue was crystallized with MTBE and collected by filtration to give the title compound (2 g, 35% yield) which was used without further purification.1H-NMR (400MHz, DMSO-d6): delta [ppm]= 8.75 (s, 1 H), 8.38 (d, 1 H), 7.78 (d, 1 H), 4.19 (s, 2H), 3.44 – 3.52 (m, 4H), 2.57 – 2.62 (m, 4H), 1.10 – 1 .23 (m, 6H).
According to the analysis of related databases, 68325-15-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; DANA FARBER CANCER INSTITUTE; SIEGEL, Stephan; SIEGEL, Franziska; SCHULZE, Volker; BERGER, Markus; GRAHAM, Keith; KLAR, Ulrich; KNUT, Eis; SUeLZLE, Detlev; BOeMER, Ulf; KORR, Daniel; PETERSEN, Kirstin; MOeNNING, Ursula; EBERSPAeCHER, Uwe; MOOSMAYER, Dieter; MEYERSON, Matthew; GREULICH, Heidi; KAPLAN, Bethany; HARB, Hassan, Youssef; DINH, Phi, Manh; (324 pag.)WO2019/81486; (2019); A1;,
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