7379-35-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7379-35-3, name is 4-Chloropyridine hydrochloride, molecular formula is C5H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 3-aminothiophenol (3.8 mL, 34 mmoles) in anh DMF (90mL) was added 4-chloropyridine hydrochloride (5.4 g, 35.6 mmoles) followed by K2CO3 (16.7 g, 121 mmoles). The reaction mixture was stirred at room temp. for 1.5 h, then diluted with EtOAc (100 mL) and water (100mL). The aqueous layer was back-extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with a saturated NaCl solution (100 mL), dried (MgSO4), and concentrated under reduced pressure. The residue was filtered through a pad of silica (gradient from 50percent EtOAc/50percent hexane to 70percent EtOAc/30percent hexane) and the resulting material was triturated with a Et2O/hexane solution to afford the desired product (4.6 g, 66percent): TLC (100 percent ethyl acetate) Rf 0.29; 1H-NMR (DMSO-d6) delta 5.41 (s, 2H), 6.64-6.74 (m, 3H), 7.01 (d, J=4.8, 2H), 7.14 (t, J=7.8 Hz, 1H), 8.32 (d, J=4.8, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7379-35-3, 4-Chloropyridine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bayer Pharmaceuticals Corp.; EP1047418; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem