Related Products of 74115-12-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-12-1, name is 5-Chloro-3-hydroxypyridine, molecular formula is C5H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
7-((Difluoromethyl)sulfonyl)-4- fluoro-2,3-dihydrospiro[indene-l ,2′-[l,3]dioxolane] (3.0 g, 9.7 mmol) was combined with 5- chloropyridin-3-ol (1.89 g, 14.6 mmol) and sodium bicarbonate (2.45 g, 29.2 mmol) then the solids were suspended in N-methylpyrrolidinone (28.5 mL). The mixture was heated to 90 C for 14 hours then stirred at ambient temperature for 34 hours. The reaction mixture was diluted with ethyl acetate and water and the layers were separated. The aqueous was washed with ethyl acetate and the combined organic layers were washed five times with water, saturated NaCl, dried over Na2S04 and concentrated in vacuo to a cream-colored solid (4.36 g). LCMS ESI (+) m z (Mu+Eta) 418, 420.
According to the analysis of related databases, 74115-12-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; WO2015/35223; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem