Reference of 74976-31-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, SMILES is ClC1=CC(NC=C2)=C2C=N1, belongs to pyridine-derivatives compound. In a article, author is Yuan, Donghe, introduce new discover of the category.
Efficient copper-catalyzed tandem oxidative iodination and alkyne-azide cycloaddition in the presence of glycine-type ligands
Tandem oxidative iodination and alkyne-azide cycloaddition reaction has provided one of the most widely used methods for preparation of 5-iodo-1,2,3-triazoles. However, stoichiometric copper salts are involved in this type of reaction in order to enhance the reaction effectiveness, which caused some problems related to toxic metal contaminations and less sustainability. In this paper, we described that a copper-catalyzed (10 mol%) tandem oxidative iodination and alkyne-azide cycloaddition could be completed in the presence of the newly-found glycine-type ligands with low-cost Nal as the iodine resource. In the novel reaction system, a wide range of terminal alkyne, organic azide and inexpensive iodide could react effectively in one pot to give structurally diverse 5-iodo-1,4-subsitutied 1,2,3-triazoles. Natural product derivatives and alkynyl pyridines that hardly react under traditional conditions could also be transferred smoothly to the target products for the first time. (C) 2020 Elsevier Ltd. All rights reserved.
Reference of 74976-31-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 74976-31-1 is helpful to your research.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem