Application of 1026201-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1026201-45-5, name is 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H5BrN2O2, molecular weight is 241.04, as common compound, the synthetic route is as follows.
SOCl2 (15 ml, 206 mmol) was added slowly to intermediate 39 (1.6 g, 6.6 mmol) while cooling on ice. The resulting solution was heated to reflux temperature for 4 h, and was then cooled to r.t. and concentrated in vacuo. The residue was triturated with DIPE and finally the product was dried. Yield: 1.7 g of intermediate 40 (99 %).
Statistics shows that 1026201-45-5 is playing an increasingly important role. we look forward to future research findings about 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid.
Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2010/70008; (2010); A1;,
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