Application of 86847-84-9 ,Some common heterocyclic compound, 86847-84-9, molecular formula is C10H13ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a dry solution OF N- (6-CHLOROPYRIDIN-2-YL)-2, 2-dimethyl propionamide (Preparation 107, 8. 0g, 37. 6MMOL) in THF (120ML), cooled TO-78C, was added dropwise, a solution of tert-butyllithium in pentane (1.7M, 48.7mL, 82. 8MMOL) over 40min. The reaction was stirred at-78C for 3h before adding a solution of iodine (11. 46g, 45. 1MMOL) in THF (40mL) dropwise. The mixture was brought up to rt and stirred for 16h. 2M HCl (30mL) was added to the reaction, and after 20min the solvent was removed in VACUO. Crude material was partitioned between ethyl acetate (200ML) and water (150ML). Organics were separated and washed with 10% sodium thiosulfate solution (4XLOOML) then NAHCO3 solution (2XLOOML), dried (MGS04) and the solvent removed in VACUO. The residue was purified by column chromatography (SIO2, CH2C12) to give the title compound. m/z (ES) = 338.93 [M+ H] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86847-84-9, N-(6-Chloropyridin-2-yl)pivalamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
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