Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N2O3
A 100-mL round- bottomed flask open to air was charged with (4-nitropyridin-2-yl)methanol (1.03 g, 6.69 mmol), EtOH (17 mL), and EtONa (1.73 g, 25.4 mmol, 3.8 equiv). The vessel was fitted with a reflux condenser and heated to reflux. After 15 h, more EtONa (2.52 g, 37.0 mmol, 5.5 equiv) was added, and the reaction mixture was let stir at reflux. After 3 h, the reaction mixture was cooled to 23 C and neutralized with aqueous 4.0 M HCI. The mixture was concentrated in vacuo to remove organic solvent and then dissolved in saturated aqueous NaHCOa. The resulting aqueous layer was extracted with CH2CI2 (3 c 30 mL) using a separatory funnel. The combined organic layers were dried over anhydrous Na2S04, filtered, and concentrated in vacuo to afford (4-ethoxypyridin-2~yl)methanol (1.03 g, quantitative yield) as a red solid which was pure by 1H NMR.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine.
Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem