Synthetic Route of 64119-42-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64119-42-2, name is Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate, molecular formula is C10H9ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(d) l-[3 -Cyano-5-(ethoxycarbonyl) -6-methylpyridine -2-yI] azetidinc -3-carboxylic acid; Ethyl 6-chloro-5-cyano-2-methylnicotinate (50.98 g, 227 mmol), azetidine-3-carboxylic acid (24.09 g, 238 mmol) and DIPEA (118.9 mL, 681 mmol) were suspended in EtOH (250 mL) and heated at reflux for 1 h. The reaction mixture was cooled to r.t and added drop- wise to KH5O4 (154.5 g, 1135 mmol) in water (3000 mL). The solids were collected by filtration and dried under vacuum to afford 1-[3-Cyano-5-(ethoxycarbonyl)-6-methylpyridine-2- yl]azetidine-3-carboxylic acid as a solid, which was used without further purification. Yield: 65.33 g (100%). 1H NMR (400 MHz, CDCl3): 6 1.37 (3H, t, J= 7.1 Hz), 2.72 (3H, s), 3.59-3.68 (1H, m), 4.31 (2H, q, J= 7.1 Hz), 4.55-4.68 (4H, m), 8.28 (1H, s). M5 m/z: 290 (M+l).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 64119-42-2, Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate.
Reference:
Patent; ASTRAZENECA AB; WO2006/73361; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem