Adding a certain compound to certain chemical reactions, such as: 1042141-37-6, Methyl 2-bromoimidazo[1,2-a]pyridine-6-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 2-bromoimidazo[1,2-a]pyridine-6-carboxylate, blongs to pyridine-derivatives compound. Application In Synthesis of Methyl 2-bromoimidazo[1,2-a]pyridine-6-carboxylate
Example 1 2-({ [2-(2-methylbiphenyl-3-yl)imidazo[l,2-a]pyridin-6-yl]methyl}amino)ethanol Step 1: (2-bromoimidazo[l, To a solution of methyl 2-bromoimidazo[l,2-a]pyridine-6-carboxylate (200 mg, 0.784 mmol) (ArkPharm, catAK-31669) in tetrahydrofuran (5.0 mL) at 0 C was added 1.0 M diisobutylaluminum hydride in tetrahydrofuran (862 mu, 0.862 mmol). The resulting mixture was sitrred at room temperature for 1 h then it was quenched with saturated NH4CI aqueous solution (1 mL), stirred for 1 h then filtered through celite. The organic layer was dried over Na2S04, filtered and concentrated. The residue was used for next step without further purification. LC-MS calculated for C8H8BrN20 (M+H)+: m/z = 227.0; found 227.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1042141-37-6, Methyl 2-bromoimidazo[1,2-a]pyridine-6-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; SHEN, Bo; LI, Jingwei; LI, Zhenwu; LIU, Kai; ZHANG, Fenglei; YAO, Wenqing; (120 pag.)WO2017/70089; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem