Extended knowledge of Methyl 6-chloro-4-methoxypicolinate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,204378-41-6, its application will become more common.

Reference of 204378-41-6 ,Some common heterocyclic compound, 204378-41-6, molecular formula is C8H8ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 6-chloro-4-methoxy-2-carboxylic acid methyl ester (2.63 g, 13.0 mmol) in dioxane (150 mL) is degassed and put under argon before Pd(dppf) (109 mg, 133 mumol) is added. To this mixture, 1-ethyl-propyl zink bromide (50 mL of a 0.5 M solution in THF, 25.0 mmol) is added dropwise. The mixture is stirred at 76°C for 15 h. The mixture is cooled to rt, diluted with water and extracted twice with EA. The combined org. extracts are dried over MgSO4, filtered and concentrated. The crude product is purified by MPLC on silica gel eluting with a gradient of EA in heptane to give 6-(1-ethyl-propyl)-4-methoxy-pyridine-2- carboxylic acid methyl ester (450 mg) as a pale yellow oil; LC-MS**: tR = 0.46 min; [M+1]+ = 238.34.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,204378-41-6, its application will become more common.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/109872; (2009); A1;,
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