With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7295-76-3, name is 3-Methoxypyridine, molecular formula is C6H7NO, molecular weight is 109.13, as common compound, the synthetic route is as follows.Safety of 3-Methoxypyridine
General procedure: To a stirred cooled (0 C) solution of 2,2,6,6-tetramethylpiperidine (1.0 mL, 6.0 mmol) in THF (5 mL) were added BuLi (1.6 M hexanes solution, 6.0 mmol) and, 5 min later, FeBr2 (0.43 g, 2.0 mmol). The mixture was stirred for 15 min at 0 C before introduction of the substrate (2.0 mmol). After 2 h at room temperature, the electrophile (6.0 mmol) was added. The mixture was stirred for 1 h before addition of H2O (10 mL) and extraction with EtOAc (3¡Á20 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated under reduced pressure.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7295-76-3, 3-Methoxypyridine, and friends who are interested can also refer to it.
Reference:
Article; Nagaradja, Elisabeth; Chevallier, Floris; Roisnel, Thierry; Jouikov, Viatcheslav; Mongin, Florence; Tetrahedron; vol. 68; 14; (2012); p. 3063 – 3073;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem