Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Madacsi, Ramona, once mentioned the application of 500-22-1, Name is 3-Pyridinecarboxaldehyde, molecular formula is C6H5NO, molecular weight is 107.11, MDL number is MFCD00006382, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Name: 3-Pyridinecarboxaldehyde.
Synthesis and biological evaluation of 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-based beta-aminonitriles and their derivatives: beta-amino carboxamides, (thio)ureas, and tetracycles
The preparation and cytotoxic characterization of 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-based beta-aminonitriles, beta-amino carboxamides, and their (thio)urea and annulated derivatives were accomplished. Following a synthetic route involving Gewald three-component reactions (G-3CR) and a Lewis acid-catalyzed iso (thio)cyanate coupling, 30 compounds were prepared for antitumor evaluation. For derivatizations, a catalytic amount of CuOAc2 (20 mol%) was essential for improving the reactivity of either the C-2 amino function of thiophene or isocyanates. The synthesized analogues demonstrated a weak to moderate antitumor activity in a low micromolar range against A549 and K562 cancer cell lines.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 500-22-1, Name: 3-Pyridinecarboxaldehyde.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem