Synthetic Route of 1335210-23-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1335210-23-5, name is 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid, molecular formula is C13H17NO8, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1; A suspension of compound 11-A (965 mg, 3.061 mmol), 2,4,6- trifiuorobenzylamine (493 mg, 3.06 mmol), and HATU (1402 mg, 3.688 mmol) in CH2C12 (15 mL) was stirred in 0 C as DIEA (2 mL, 11.48 mmol) was added.After 1.5 hours at 0 C, the reaction mixture was diluted with ethyl acetate, and washed with water (twice). After the aqueous fractions were extracted with ethyl acetate, the organic fractions were combined, dried (Na2S04), and concentrated. The residue was purified by CombiFlash (40 g column) using hexanes-ethyl acetate as eluents to obtain compound 11-B. 1H NMR (400 MHz, Chloroform-d) delta 10.30 (t, J = 5.9 Hz, 1H), 8.40 (s, 1H), 6.79 – 6.51 (m, 2H), 4.65 (d, J = 5.6 Hz, 2H), 4.48 (t, J = 4.8 Hz, 1H), 4.01 (d, J = 4.8 Hz, 2H), 3.97 (s, 3H), 3.94 (s, 3H), 3.38 (s, 6H). 19F NMR (376 MHz, Chloroform-d) delta – 109.07 – -109.35 (m, IF), -1 1 1.93 (t, J = 6.9 Hz, 2F). LCMS-ESI+ (m/z): [M+H]+ calculated for C20H22F3N2O7: 459.14; found: 459.2.
According to the analysis of related databases, 1335210-23-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.; JI, Mingzhe; LAZERWITH, Scott E.; PYUN, Hyung-Jung; WO2015/6731; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem