The synthetic route of 1156542-30-1 has been constantly updated, and we look forward to future research findings.
In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1156542-30-1, name is 2-Bromo-5-fluoro-4-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. Safety of 2-Bromo-5-fluoro-4-(trifluoromethyl)pyridine
To 12 ml of N,N-dimethylformamide were added 0.8 g of 2-bromo-5-fluoro-4- trifluoromethylpyridine, 1.41 g of zinc cyanide and 0.28 g of tetrakistriphenylphosphinepalladium, and the mixture was stirred at 950C for 14 hours. After allowing to cool, the reaction solution was poured into water, and the resultant solution was extracted with diethyl ether three times, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.5 g of 5- fluoro-4-trifluoromethylpyridine-2-carbonitrile. 5-Fluoro-4-trifluoromethylpyridine-2-carbonitrile1H-NMR: 7.96 (d, IH), 8.79 (s, IH)
The synthetic route of 1156542-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66786; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem