Adding a certain compound to certain chemical reactions, such as: 117519-09-2, 3-Amino-2-chloro-6-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H4ClF3N2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H4ClF3N2
To a solution of 2-chloro-6-(trifluoromethyl)pyridin-3-amine (8) (5.0 g, 25 mmol) in acetonitrile (60 mL) was added NBS (5.0 g, 28 mmol). The mixture was stirred at reflux for 3 hours, concentrated and purified by silica gel chromatography and eluted with petroleum ether which gave 4-bromo-2-chloro-6-(trifluoromethyl)pyridin-3-amine (9) as a red semi-solid (6.0 g, 86% yield). 1H NMR (400 MHz, CDCl3) delta 7.68 (s, 1H), 4.93 (s, 2H). LCMS (ESI) m/z 275, 277 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,117519-09-2, 3-Amino-2-chloro-6-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; PLANKEN, Simon; CHENG, Hengmiao; COLLINS, Michael Raymond; SPANGLER, Jillian Elyse; BROOUN, Alexei; MADERNA, Andreas; PALMER, Cynthia; LINTON, Maria Angelica; NAGATA, Asako; CHEN, Ping; US2019/233440; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem