Extracurricular laboratory: Synthetic route of 117977-21-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117977-21-6, 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 117977-21-6, name is 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole. A new synthetic method of this compound is introduced below., 117977-21-6

Example 3 Preparation of 2-[[[4-(3-methoxy propoxy)-3-methyl-2-pyridinyl]methyi]- sulfinyl]-lH-benzimidazole sodium (Rabeprazole Sodium) 2-[[ [4 -(3 -methoxy-propoxy)-3 -methyl-2-pyridinyl]methyl] -thio]-1 H benzimidazole (25 g) was suspended in 500 ml of Purified Water, Sodium hydroxide (5 g) and Pyridine (12.5 ml). To this was slowly added about 160 g of Sodium hypochlorite solution having a chlorine content of 3.2 % at 5-10 C in 2 hours. The reaction mass was maintained at 5 – 8 C for 2 hours. After completion of the reaction, excess Sodium hypochlorite was decomposed using 5% aqueous Sodium thiosulphate solution. The reaction mass was then saturated with 150 g of Sodium chloride and extracted with 250 ml of dichloromethane twice. The organic layer was then dried over anhydrous Sodium sulphate. Concentrating the organic layer under vacuum yielded a residue to which 125 ml of Ethyl acetate was added and heated to 45 – 50 C for dissolution. This solution was slowly added to 500 ml of n-Heptane under stirring and stirred for 2 hours. EPO The solids were filtered under nitrogen atmosphere, washed with n-Heptane and dried in an oven at 45-50 C to give 20 g of Rabeprazole sodium.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117977-21-6, 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole, and friends who are interested can also refer to it.

Reference:
Patent; CIPLA LIMITED; PATHI, Srinivas, Laxminarayan; KANKAN, Rajendra, Narayanrao; RAO, Dharmaraj, Ramachandra; WO2006/117802; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem