Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine. A new synthetic method of this compound is introduced below., name: N-((6-Chloropyridin-3-yl)methyl)ethanamine
Synthesis Example 3 2-chloro-5-[N-trifluoroacetyl-N-ethyl]aminomethylpyridine (Compound 21) A solution of 140 mg (0.67 mmol) of trifluoroacetic anhydride dissolved in 5 mL of anhydrous dichloromethane was added dropwise under ice cooling to a solution of 120 mg (0.70 mmol) of ethyl-(2-chloro-5-pyridylmethyl)amine synthesized by the method described in U.S. Patent Application Publication No. 2009306041 and 101 mg (1 mmol) of triethylamine dissolved in 5 mL of anhydrous dichloromethane. Following dropwise addition, the system was stirred overnight at room temperature, then the reaction mixture was washed with, in order, ice-cooled 1% aqueous sodium hydroxide, water, 1% hydrochloric acid, then water, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, giving 107 mg the target compound (yield, 78%).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine.
Reference:
Patent; MEIJI SEIKA PHARMA CO., LTD.; KAGABU, Shinzo; MITOMI, Masaaki; KITSUDA, Shigeki; HORIKOSHI, Ryo; NOMURA, Masahiro; ONOZAKI, Yasumichi; US2013/150414; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem