Synthetic Route of 1226878-98-3 , The common heterocyclic compound, 1226878-98-3, name is 2-Chloro-5-iodo-4-methoxypyridine, molecular formula is C6H5ClINO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
j00505j To a solution of compound B-116 (4.0 g, 7.4 mmol) in acetic acid (30 mL) was added hydrogen bromide (40% in water, 23 g, 11 immol). The vessel was sealed and heated to 110 C for 4 hours. On completion, the mixture was concentrated in vacuo. The residue was dissolved in methanol (20 mL) and triethylamine (20 mL), concentrated again in vacuo and purified by silica gel chromatography [dichloromethane: methanol = 30:11 to give compound B-117 (3.0 g, 75% yield) as a white solid. ?H-NMR (CD3OD, 400 MHz): 8.33 (s, 1H), 6.73 (s, 1H).
The synthetic route of 1226878-98-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem