Related Products of 1256823-07-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256823-07-0, name is 5-Bromo-4-methoxypicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile [0324] To a stirred solution of 4-methyl-lH-imidazole (580 mg, 7.04 mmol) in acetonitrile (24 mL) under argon atmosphere were added potassium carbonate (1.3 g, 9.38 mmol) and 18 crown-6 (2.47 g, 9.38 mmol) at RT. The reaction mixture was stirred at 60 C for 2 h. Then 5-bromo-4-methoxypicolinonitrile (1 g, 4.69 mmol) was added to the reaction mixture and stirred at reflux for 18 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography using 90%> EtOAc:hexanes to afford 4-methoxy-5-(4-methyl-lH-imidazol-l-yl) picolino nitrile (250 mg, 25%) as a yellow solid. 1H-NMR (CDC13, 500 MHz): delta 8.58 (s, 1H), 7.82 (s, 1H), 7.39 (s, 1H), 6.99 (s, 1H), 401 (s, 3H), 2.23 (s, 3H); LC-MS: 215 (M+l); (column; X-Bridge C-18 (50 3.0 mm, 3.5 mu); RT 2.45 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: EtOAc (R 0.2).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
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