Extracurricular laboratory: Synthetic route of 1452-63-7

The synthetic route of 1452-63-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1452-63-7 , The common heterocyclic compound, 1452-63-7, name is Picolinohydrazide, molecular formula is C6H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) Pyridine-2-carboxylic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide A suspension of 9.24 g (0.035 mol) 2-(phenylsulfonyl)-ethanimidic acid ethyl ester hydrochloride in 100 ml chloroform was treated with 35 ml 1N aqueous sodium hydoxide. 14 ml of a saturated aqueous sodiumbicarbonate solution was added and the mixture was extracted with chloroform. The extracts were combined and dried with sodium sulfate and the solvents were distilled off under reduced pressure. The resulting colorless oil was stirred together with 5.12 g (0.037 mol) 2-picolinyl hydrazide in 60 ml chloroform for 24 hours at 50 C. The resulting precipitate was filtered off and dried. A quantitative yield of pyridine-2-carboxylic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide was obtained as white crystals. MS m/e (%): 319 (M+H+, 100).

The synthetic route of 1452-63-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US6355653; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem