Related Products of 1480-65-5, Adding some certain compound to certain chemical reactions, such as: 1480-65-5, name is 5-Chloro-2-fluoropyridine,molecular formula is C5H3ClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1480-65-5.
To a suspension of cesium carbonate (3.76 g, 11.5 mmol) in DMF (20 mL) at room temperature was added 5-chloro-2-fluoropyridine (1.00 mL, 9.96 mmol) and benzylmercaptan (1.15 mL, 9.80 mmol). The reaction mixture was stirred at room temperature for 16 h and heated to 60 °C for 6 h. The reaction mixture was diluted with Et20. The organic phase was washed with water (2 x), brine and dried over MgS04. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel ( 5percent to 10percent EtOAc in heptane) to give the title compound (2.33 g, 9.88 mmol, 101percento yield) as a colorless oil that was used without further purification in the next step. MS) m/z = 236.1 [M+H]+
According to the analysis of related databases, 1480-65-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; MINATTI, Ana Elena; LOW, Jonathan, D.; ALLEN, Jennifer, R.; AMEGADZIE, Albert; BROWN, James; FROHN, Michael, J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul, E.; LOPEZ, Patricia; MA, Vu Van; NISHIMURA, Nobuko; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert, M.; SHAM, Kelvin; SMITH, Adrian, L.; WHITE, Ryan; XUE, Qiufen; WO2014/138484; (2014); A1;,
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