Electric Literature of 1513-66-2 ,Some common heterocyclic compound, 1513-66-2, molecular formula is C5H3F2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
500 g of DMF was added to a 1000 mL four-necked flask, 100 g of compound A was charged,113.6 g of potassium carbonate and 5 g of tetrabutylammonium bromide, the temperature was raised to 60 C, and 92.6 g of the product was added dropwise2,3-difluoropyridine in 50 g of DMF in a mixed solution at a controlled temperature of 65 to 70 C,The reaction is about 2 hours, the reaction is completed, added to 1000 g of water, the pH is adjusted to 7 to 8 with hydrochloric acid,Stirring for 1 hour, filtering, solid is the etherification (compound I), drying.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1513-66-2, 2,3-Difluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Fuding Chemical Co., Ltd.; Liu Dongwei; Cheng Lizhong; Chang Qing; Dong Hailong; Zhu Ruiyu; Gu Junkun; (16 pag.)CN106632045; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem