Adding a certain compound to certain chemical reactions, such as: 189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]pyridine-3-acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 189005-44-5, blongs to pyridine-derivatives compound. SDS of cas: 189005-44-5
To a solution of 1 g (0.025 mole) of sodium hydroxide and 40 ml of water 5.6 g (0.02 mole) of [6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetic acid are added, whereupon 2.5 ml (3.6 g, 0.021 mole) of benzyl bromide are added dropwise. The reaction mixture is heated to boiling for an hour and a half, then cooled to room temperature and extracted twice with 50 ml of dichloro methane each. The organic phase is washed with 30 ml of a 10 % sodium hydroxide solution and 50 ml of water, dried over anhydrous sodium sulfate, filtered and evaporated. The oily residue is triturated with petroleum ether. The crystalline product is filtered and washed with petroleum ether. Thus 5.3 g of benzyl-[6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetate are obtained, yield 71.0 %. Mp.: 106 – 107 C. IR (KBr) 3032, 2920, 1719, 1538, 1501, 1450, 1409, 1378, 1346, 1319, 1304, 1266, 1247, 1180, 1141, 1122, 1050, 1020, 998, 970, 896, 825, 812, 740, 694, 581, 504. 1H-NMR (CDCl3): delta, ppm 7.79 (1H, s, H-5); 7.69 (2H, d, J 7.8 Hz, H-2′,6′); 7.55 (1H, d, J 9.1 Hz, H-8); ~ 7.3 (5H, m, ArH); 7.22 (2H, d, J 7.8 Hz, H-3′,5′); 7.04 (1H, dd, J 9,1 Hz, H-7); 5.18 (2H, s, PhCH2); 4.04 (2H, s, CH2); 2.39 (3H, s, CH3-4′); 2.28 (3H, s, CH3-6). 13C-NMR (CDCl3): delta, ppm 169.3 (C=O); 144.3 (C-8a); 143.8 (C-2); 137.5 (C-4′); 131.0 (C-1′); 129.2 (C-3′,5′); 128.3 (C-2′,6′); 127.6 (C-7); 122.0 (C-5); 121.3 (C-6); 116.6 (C-8); 112.1 (C-3); 67.2 (PhCH2); 30.8 (CH2); 21.2 (CH3-4′); 18.3(CH3-6).
The synthetic route of 189005-44-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EGIS GYOGYSZERGYAR RT.; EP1259509; (2005); B1;,
Pyridine – Wikipedia,
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