In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 195044-14-5, name is 2-Bromo-6-tert-butylpyridine, the common compound, a new synthetic route is introduced below. Formula: C9H12BrN
Next, the threeneckflask, to introduce a nitrogen atmosphere, the above synthesis of 2bromo6tbutylpyridine 3.65g, tetrahydrofuran (dehydration solventcommercially available) 50mL, and cooled to 78. Thereto, a 1.6M solution of nbutyllithiumin hexane was added dropwise 10.0mL, was stirred for 30 minutesat 78. Here, by the addition of crushed dry ice and slowly a large excess, and the mixture was stirred at room temperature for 2 hours. By extraction andseparated with the addition of 100mL of water, 50mL of ethyl acetate was recovered aqueous layer (pH ~ 11). With respect to the aqueous layer, concentratedhydrochloric acid to pH ~ 2 was added little by little and, by concentration of the resulting organic layer was extracted three times with 50mL of ethyl acetate, togive 2g Compound A214.
The synthetic route of 195044-14-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG CHEMICAL CO., LTD; PARK, JONG HO; SAH, KONG CHUN; KIM, SUNG HYUN; BAEK, GYUNG LIM; RYU, CHANG HYUN; (91 pag.)KR2015/128789; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem