Synthetic Route of 109306-86-7 ,Some common heterocyclic compound, 109306-86-7, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 117.5 mg of 2- (2-bromophenyl) pyridine (0.5 mmol)And 70.15 mg of potassium methoxide (1 mmol) were dissolved in 1 mL of deuterated acetonitrile, and 200 muL of hexamethyldisilane (1 mmol) was added dropwise to the mixture, and the mixture was stirred at room temperature for 12 h. After completion of the reaction, 10 mL of water was quenched and extracted with 30 mL of ether three times. The organic phase was collected and the solvent was removed under reduced pressure. The eluent was petroleum ether: ethyl acetate = 10: 1 (v / v) to give 68 mg of 2- (2-deuterated) pyridine (pale yellow liquid in 87% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109306-86-7, 2-(2-Bromophenyl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wuhan University; Liu Wenbo; Wang Xin; Zhong Dayou; (23 pag.)CN106928117; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem