Adding a certain compound to certain chemical reactions, such as: 861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine
104a 1-(2-(2-tert-butylphenoxy)pyridin-3-yl)-3-(2, 4-dichlorophenyl) thiourea [00324] A solution of lb (40 mg, 0.17 mmol) and 2,5- dichlorophenylisothiocyanate (37 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60C for 6 h. More 2,5-dichlorophenylisothiocyanate (37 mg, 0.18 mmol) was added and the mixture was heated at 60C for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluant. Half of the material was carried to the next step without further purification, the other half was purified by preparative HPLC (continuous gradient from 40% B to 100%, B; A = 90: 10: 0.1 H20 : MeOH: TFA; B = 90 : 10: 0.1 MeOH: H2O : TFA) to afford 104a (8 mg, 43%). 1H NMR (400 MHz, CD30D) 8 ppm 1. 38 (m, 9 H), 6.93 (dd, J=7. 83,1. 52 Hz, 1 H), 7.15 (m, 3 H), 7. 31 (dd, J=8. 59, 2.27 Hz, 1 H), 7.44 (dd, J=7. 83,1. 77 Hz, 1 H), 7.52 (d, J=2. 53 Hz, 1 H), 7.68 (d, J=8. 59 Hz, 1 H), 7.90 (dd, J=5. 05,1. 77 Hz, 1 H), 8.35 (dd, J=7. 71,1. 89 Hz, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/70920; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem