Application of 133928-73-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 133928-73-1, name is 2-Chloro-3-methyl-4-pyridinecarboxylic Acid. This compound has unique chemical properties. The synthetic route is as follows.
2-Chloro-3-methyl-4-pyridinecarboxylic acid (30 g; 174 mmol) was dissolved in pyri- dine (250 ml) and cooled to 0 0C. Methanesulfonyl chloride (13.6 ml) was then added dropwise and the reaction mixture was stirred at 0 0C for 1 hour. NH3 (gas) was added under pressure and the reaction mixture was stirred at room temperature for 1 h. After the reaction had reached completion, the excess NH3 was removed in vacuo. The reaction mixture was then cooled to 0 0C, methanesulfonyl chloride (140 ml) was added and the reaction mixture stirred at room temperature overnight. The mixture was then poured into 0.1 M HCl (200 ml ) at 0 0C (with care), and adjusted to pH =7 with 1 M NaOH. The reaction mixture was extracted with EtOAc (2 x 100 ml), washed with brine, dried (MgSO4), filtered and the solvent evaporated in vacuo. The residue was purified by flash column chromatography over silica gel (Biotage flash purification system; gradient: EtO Ac/heptane from 15/85 to 30/70). The product fractions were collected and the solvent was evaporated in vacuo. Yield: 12.6 g of Dl.
According to the analysis of related databases, 133928-73-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/135944; (2009); A1;,
Pyridine – Wikipedia,
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