Reference of 72587-18-9 ,Some common heterocyclic compound, 72587-18-9, molecular formula is C6H4ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(4) 2.50 g of 6-chloro-3- (ethanesulfonyl) pyridine-2-carboxylic acid,And 30 mL of toluene were added 1.31 g of thionyl chloride,And one drop of DMF were heated under reflux for 3 hours.The reaction mixture was concentrated and dissolved in 30 mL of tetrahydrofuran, and under ice cooling,1.97 g of 3-amino-2-chloro-5- (trifluoromethyl) pyridine,And triethylamine (1.10 g) were added dropwise thereto.After stirring at room temperature for 3 hours,The reaction mixture was added to ice water and extracted with ethyl acetate.The obtained organic layer was washed with saturated brine,After drying over anhydrous magnesium sulfate, it was concentrated.The residue was subjected to silica gel column chromatography,2.4 g of Intermediate 36 described below was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72587-18-9, 2-Chloro-5-(trifluoromethyl)pyridin-3-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sumitomo Chemical; Ikari, Kaori; (123 pag.)JP2019/6686; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem