In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid, the common compound, a new synthetic route is introduced below. Formula: C7H6N2O4
REFERENTIAL EXAMPLE 3 Synthesis of N,N-diethyl 2-methyl-5-nitronicotinamide (No. 98) In dry chloroform were dissolved 0.3 g of 2-methyl-5-nitronicotinic acid and 1.5 ml of diethylamine. After addition of 10 g of phosphorous pentaoxide, the mixture was stirred with heating at 55 – 60 C. for 3 hours. After cooling, the chloroform portion was separated and evaporated under reduced pressure. The residue was, after addition of water, neutralized with sodium hydrogen carbonate and extracted with ethyl acetate. The extract was concentrated and purified on a silica gel column to give 0.25 g of a colorless oil. Analysis for C11 H15 N3 O3:
The synthetic route of 59290-81-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sankyo Company Limited; US4053608; (1977); A;,
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