Application of 17997-47-6, Adding some certain compound to certain chemical reactions, such as: 17997-47-6, name is 2-(Tributylstannyl)pyridine,molecular formula is C17H31NSn, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17997-47-6.
A high-pressure vial was filled with the (S)-1-(4-bromobenzyl)-N-(1-(4-nitrophenyl)ethyl)- 1H-indole-5-carboxamide (37 mg, 0,08 mmol, 1 equiv), 2-(tributylstannyl)pyridine (28 muL, 0.09 mmol, 1.1 equiv), LiCl (10 mg, 0.24 mmol, 3 equiv), Pd(PPh3)4(9 mg, 0.008 mmol, 0.1 equiv), and anhydrous DMF (1 mL). The mixture was degassed for 5 min under argon atmosphere and the vial was sealed. The reaction mixture was heated at 120C for 1 h under microwaves. The solution was then concentrated in vacuo, filtered and purified by preparative HPLC to afford a beige powder (18 mg, 0.4 mmol, 50%). ESI-MS (m/z): 477 [M+H]+.
According to the analysis of related databases, 17997-47-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITY OF TOLEDO; GRIFFIN, Patrick R.; KAMENECKA, Theodore Mark; LECKA-CZERNIK, Beata; WO2015/161108; (2015); A1;,
Pyridine – Wikipedia,
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