Electric Literature of 20260-53-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 20260-53-1 as follows.
A suspension of /e/7-butyl 5-(6-acetoxy-2-(3-aminophenyl)quinazolin-4- y.amino)- l H-indazole-1-carboxylate (0 5Og, 0 98 mmol), nicotinoyl chloride hydrochloride (0 224g, 1 26 mmol) and DIEA (0 45g, 3 48 mmol) in CH2Cl2 (15 niL) was stirred at RT for 7 h The volatiles were removed in vacuo and the residue was purified by preparative TLC (SiO2, CH2Cl2-MeOH 9.1 ) to give the product te/7-butyl 5-(6-acetoxy-2- (3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-l -carboxylate (0.374g, 0 608mmol, 62%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20260-53-1, its application will become more common.
Reference:
Patent; SURFACE LOGIX, INC.; SWEETNAM, Paul; BARTOLOZZI, Alessandra; CAMPBELL, Anthony; COLE, Bridget; FOUDOULAKIS, Hope; KIRK, Brian; SESHADRI, Hemalatha; RAM, Siya; WO2010/104851; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem