Reference of 1167056-96-3, Adding some certain compound to certain chemical reactions, such as: 1167056-96-3, name is 3-Bromo-5-chloro-1H-pyrrolo[2,3-c]pyridine,molecular formula is C7H4BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1167056-96-3.
To a stirred solution of 3-bromo-5-chloro- 1H- pyrrolo[2,3-c]pyridine (AJ-2) (2.9 g, 12.6 mmol) in anhydrous DMF (100 mL) was added 2- chloro-6-(trifluoromethyl)benzoyl chloride (4.6 g, 18.9 mmol) and NaH (60%) (1 g, 25.2 mmol). The solution was stirred at r.t for 2 hours. The solution was quenched with H20 (400 mL). The suspension was extracted with EtOAc (150 mL x 3). The combined organic layer was washed with H20 (100 mL x 2) and brine (100 mL x 2) and dried over anhydrous Na2S04. The solution was evaporated and dried over vacuo and 5.7 g product was obtained. LCMS (ESI) calc’d for Ci5H6BrCl2F3N20 [M+H]+: 437, found: 437.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1167056-96-3, 3-Bromo-5-chloro-1H-pyrrolo[2,3-c]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; ZHANG, Dongshan; WO2014/26327; (2014); A1;,
Pyridine – Wikipedia,
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