Electric Literature of 76015-11-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76015-11-7, name is 3-Methoxy-2-methylpyridin-4(1H)-one. A new synthetic method of this compound is introduced below.
3-Methoxy-2-methyl-4(1H)-pyridone (27.8g, 0.2 mol) was added to phosphorus oxychloride (200 mL) and the resulting mixture was heated under nitrogen at 90 oC for 18 h. The homogeneousmixture was cooled to 20 oC and concentrated under reduced pressure.The residue was dissolved in ice-water. Adjustment of the solution to pH 12with 40% sodium hydroxideresulted in a turbid suspension which was extracted with dichloromethane (3 x100 mL). The combined organic extracts were combined, washed with water. After drying the extract with MgSO4,the DCM was removed by rotary evaporation to give the title product (30.2 g,96%). 1H NMR (CDCl3) d 8.14(d, 1H, J = 5.32 Hz), 7.17 (d, 1H, J = 5.10 Hz), 3.85 (s, 3H), 2.54 (s, 3H). m/z (ESI) 157.91 (M+ +1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76015-11-7, its application will become more common.
Reference:
Article; Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 9; (2013); p. 2808 – 2811;,
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