In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 851386-40-8, name is 4-Chloro-2,5-difluoropyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C5H2ClF2N
4-chloro-2,5-difluoropyridine (1.00 eq.), 3,5-bis (trifluoromethyl) phenylboronic acid ester (1.30 eq.), Pd2(dba)3(0.02 eq.) 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) (0.08 eq.) and tribasic potassium phosphate (2.50 eq.) were heated at 110C In a dioxane / water mixture (ratio of 10: 1) for 1.5 hours. Add Celite (R) and activated carbon to the reaction mixture and stir at 110 C for 10 minutes. Subsequently, the reaction mixture is heat filtered and the residue is washed with dioxane. After concentrating the solvent under reduced pressure, the residue is dissolved in ethyl acetate and washed with water and saturated sodium chloride solution. The organic phase is dried over MgSO4 and the solvent is evaporated under reduced pressure. The crude product Z1 obtained is purified by MPLC and the product is obtained as a solid (83% yield).
The synthetic route of 851386-40-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Si Nora Geembeha; Al Ha-ma-a-reu-ho-na-e-seu-te-ban; (77 pag.)KR2019/24780; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem