Extracurricular laboratory: Synthetic route of (4-Chloro-5-fluoropyridin-2-yl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113209-90-8, (4-Chloro-5-fluoropyridin-2-yl)methanol, and friends who are interested can also refer to it.

Application of 113209-90-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 113209-90-8, name is (4-Chloro-5-fluoropyridin-2-yl)methanol. A new synthetic method of this compound is introduced below.

(v) Substituting 2-hydroxymethyl-4-chloro-5-fluoropyridine (2.5 g) for 2-hydroxymethyl-3-fluoro-4-chloropyridine and using corresponding molar proportions of the other reagents in the method of Example 27(v), gave 2-hydroxymethyl-4-morpholino-5-fluoropyridine (2.08 g) m.p. 134-136 (from acetonitrile).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113209-90-8, (4-Chloro-5-fluoropyridin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; SmithKline & French Laboratories Limited; US5250527; (1993); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem