Related Products of 13296-04-3 ,Some common heterocyclic compound, 13296-04-3, molecular formula is C11H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 159; A mixture of EXAMPLE 153 (69.2 rag), 4~pyridin-4-ylphenylamine (37.8 mg), palladium (II) acetate (3.0 mg), 4s5-bis(diphenylphosphiiio)-9,9-dirnethylxanthene (9.6 mg), cesium carbonate (141.6 mg) and dioxane (2.5 ml) were heated in a microwave at 16O0C for 40 minutes. The solvent was removed and the residue purified by flash chromatography using 20: 1 dichloromethane/methanol. Further purification by reverse phase HPLC afforded the title compound (12.8 mg, 13%). 1H NMR (DMSOd6) delta 10.40 (s, IH), 9.84 (s, IH), 8.81 (d, J=6.8 Hz, 2H), 8.38 (d, J=5.8 Hz, IH), 8.24 (d, J=6.8 Hz, 2H), 7.94-8,04 (m, 5H), 734 (d, J=5.8 Hz, IH)1 1..55-1 .75 (m, 6H), 1.27-1.36 (m, 2H), 1.17 (d, J=6.8 Hz, 3H), 0.87-1.12 (m, 4H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13296-04-3, its application will become more common.
Reference:
Patent; ABBOTT LABORATORIES; WO2007/140233; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem