Related Products of 6623-21-8 ,Some common heterocyclic compound, 6623-21-8, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4,6-dimethylpyridine-3-carbonitrile (0.15 g , 1 .135 mmol) in MeOH (150 ml) was subjected to the H-Cube with 10% palladium on carbon at a flow rate of 1 ml / min using at 50 bar and room temperature into a solution of 1 M HCI (1 ml). The solvent was evaporated in vacuo to give the title compound (190 mg, 64%) as a white solid. Used without purification.1 H-NMR (DMSO-d6, 500 MHz): d[ppm]= 8.74 – 8.66 (m, 1 H), 8.62 – 8.42 (m, 3H), 7.76 – 7.64 (m, 1 H), 4.23 – 4.13 (m, 2H), 2.66 – 2.63 (m, 3H), 2.58 – 2.54 (m, 3H)HPLCMS (Method E): [m/z]: 136.9 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6623-21-8, 4,6-Dimethylnicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VIFOR (INTERNATIONAL) AG; DUeRRENBERGER, Franz; BUHR, Wilm; BURCKHARDT, Susanna; BURGERT, Michael; KALOGERAKIS, Aris; REIM, Stefan; MANOLOVA, Vania; BOYCE, Susan; YARNOLD, Christopher John; PENA, Paula; SHEPHERD, Jon; LECCI, Cristina; JARJES-PIKE, Richard; SCOTT, John; (416 pag.)WO2017/68089; (2017); A2;,
Pyridine – Wikipedia,
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