Extracurricular laboratory: Synthetic route of 49669-13-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49669-13-8, 2-Acetyl-6-bromopyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 49669-13-8, 2-Acetyl-6-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6BrNO, blongs to pyridine-derivatives compound. Formula: C7H6BrNO

A solution of l-(6~bromorhoyridin-2-yl)ethanone (5 g, 25.0 mmol) in diethyl ether (77 ml) at 00C was treated with methyl magnesium bromide (8.33 ml, 25.0 mmol). After 3 hours, water was added to quench excess methyl magnesium bromide, and then concentrated aqueous hydrogen chloride solution was added until two layers were obtained. The layers were separated and the aqueous layer was extracted with diethyl ether (3 x 50 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated to yield the title compound. LRMS (APCI) calc’d for C8H1 jBrNO [M+H]+: 216, Found: 216.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49669-13-8, 2-Acetyl-6-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; MACHACEK, Michelle, R.; HAIDLE, Andrew; ZABIEREK, Anna, A.; KONRAD, Kaleen, M.; ALTMAN, Michael, D.; WO2010/11375; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem