Electric Literature of 67443-38-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine. A new synthetic method of this compound is introduced below.
a) 5 -bromo-2-(methyloxy)-3 -nitropyridine. To a stirred solution of 5-bromo-2-chloro-3-nitropyridine (86 mmol) in methanol (75 mL) at 0 0C was added drop wise a solution of 25% w/w sodium methoxide in methanol (20 mL, 87 mmol) and methanol (20 mL) over 10 min. After stirring at 0 0C for 1 h the reaction was allowed to warm to room temperature and stirred for 18 h. The reaction was concentrated under vacuum to approximately half its volume then poured into ice water (-500 mL). The precipitate that formed was filtered, washed with cold water, and dried under vacuum to give the title product (98%) as a pale yellow solid. MS(ES)+ m/e 233.2 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67443-38-3, its application will become more common.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/39140; (2009); A1;,
Pyridine – Wikipedia,
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