In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103058-87-3, name is 5-Bromo-2-methoxynicotinaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 103058-87-3
a) 5-Bromo-2-methoxv-3- (4-methoxv-but-1 (E, Z)-envl)-pvridine; 2. 45 ml of a 1M solution of sodium-bis(trimethylsilyl) amide in tetrahydrofuran are added. to a suspension of 2. 4 mmol (3-methoxy-propyl)-triphenyl-phosphonium bromide [111088-69-8] in 8 mi tetrahydrofuran unter an argon atmosphere at 0C. The reaction mixture is stirred for 30 minutes at 0C and then 1. 6 mmol 5-bromo-2-methoxy-pyridine-3-carbaldehyde [103058-87- 3] are added. The reaction mixture is warmed to room temperature and then diluted with tert- butyl methyl ether. The solution is washed with saturated aqueous sodium hydrogencarbonate solution. The organic layer is dried over sodium sulphate, filtered and concentrated. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F) and identified based on its Rf value
The synthetic route of 103058-87-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2005/90304; (2005); A1;,
Pyridine – Wikipedia,
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