Extracurricular laboratory: Synthetic route of 5-Bromo-3-chloropicolinaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 885168-04-7, 5-Bromo-3-chloropicolinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

To a stirred solution of 5-bromo-3-chloropicolinaldehyde (8.5 g, 38.6 mmol, I eq) in THE(135 mL) was added allylbromide (5.0 mL, 90.6 mmol, 1.5 eq) and sat. NH4CI solution followed by zinc dust (5.0 g, 77.3mmol, 2 eq) . After complete addition the RM was stirred for 2 h at RT .Then the RM was diluted with water (100 mL) and extracted with EtOAc (3×100 mL) , dried over anhydr. Na2SO4 and evaporated under reduced pressure to give crude product which was purified by CC to afford 1-(5-bromo-3-chloropyridin-2- yl)but-3-en-1-ol(4.5 g, 44%) as an off white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem