Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 944401-56-3, name is 5-Bromo-4-(trifluoromethyl)pyridin-2-amine. A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-4-(trifluoromethyl)pyridin-2-amine
Example 9: Preparation of 5-(1 -ethoxyvinyl)-4-(trifluoromethyl)pyridin-2 -amine Bis(triphenylphosphine)palladium(ll)dichloride (0.74g, 1.0373 mmol) and 5-bromo-4- (trifluoromethyl)pyridin-2-amine ( 5 g, 20.75mmol) were stirred in dimethylformamide(10 mL) under nitrogen and the tributyl(1-ethoxyvinyl)stannane (7.5g, 20.75 mmol) was added. The mixture was heated to 80C for 2h, then to 100 degrees for a further 2h). The mixture was poured into saturated brine (250 mL) and was extracted with three portions of dichloromethane. The extracts were dried over anhydrous magnesium sulphate, and the solution was evaporated, giving an orange oil (4.0g, 83%) H NMR (CDCI3) 8.19(s, 1 H); 6.70(s, 1 H); 4.77(bs, 2H); 4.28(d,1 H); 4.23(d, 1 H); 3.86(q, 2H); 1.35(t,3H).
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; CLOUGH, John Martin; BOEHMER, Jutta Elisabeth; PHADTE, Mangala; SONAWANE, Ravindra; LONGSTAFF, Adrian; MORRIS, James Alan; DESSON, Timothy Robert; HOTSON, Matthew Brian; RUSSELL, Sally; LING, Kenneth; BARNETT, Susan Patricia; BACON, David Philip; MOSELEY, Donn Warwick; MOUND, William Roderick; DOWLING, Alan John; WO2015/18432; (2015); A1;,
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