Application of 944401-65-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine, molecular formula is C5H4BrFN2, molecular weight is 191, as common compound, the synthetic route is as follows.
Synthesis of 5-cyclopropyl-6-fluoropyridin-2-amine. A solution of 5-bromo-6-fluoropyridin-2-amine (3.0 g, 15.8 mmol), cyclopropylboronic acid (2.04 mg, 23.7 mmol), Pd(OAc)2 (354 mg, 1.58 mmol), PCy3 (886.2 mg, 3.16 mmol) and K3PO4(6.7 g, 31.6 mmol) in dioxane/H2O (30 mL/3 mL) was stirred at 100 C. for 16 h. Then the reaction mixture was diluted with H2O (50 mL) and extracted with EtOAc (100 mL*3). The combined organic layers were dried over Na2SO4 and concentrated to give the desired compound 5-cyclopropyl-6-fluoropyridin-2-amine (yellow oil, 2.2 g). ESI-MS [M+H]+: 153.2.
Statistics shows that 944401-65-4 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-fluoropyridin-2-amine.
Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
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