Related Products of 50501-38-7 , The common heterocyclic compound, 50501-38-7, name is 6-(Hydroxymethyl)picolinonitrile, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Hydroxy-methylpyridine 3b, 7, or 13, 1.9 mmol, was dissolved in 25 mL of 1,2-dichloroethane, 1.65 g (19 mmol) of activated manganese dioxide was added, and the mix-ture was stirred for 6 h at 50°C. The precipitate was filtered off, the filtrate was evaporated under reduced pressure, and the residue was used in the next step without additional purification.
The synthetic route of 50501-38-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Krinochkin; Kopchuk; Chepchugov; Kovalev; Zyryanov; Rusinov; Chupakhin; Russian Journal of Organic Chemistry; vol. 53; 7; (2017); p. 963 – 970; Zh. Org. Khim.; vol. 53; 7; (2017); p. 951 – 958,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem