Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54127-30-9, name is (5,6-Dichloropyridin-3-yl)methanol. A new synthetic method of this compound is introduced below., Safety of (5,6-Dichloropyridin-3-yl)methanol
The intermediate, ethyl (E)-3-{2-[3′-(l-adamantyl)-4′-hydroxyphenyl]-3-chloro-5- pyridinyl}-2-propenoate was prepared as follows.; a) Ethyl (?)-3-(5,6-Dichloro-2-pyridinyl)-2-propenoate.; A reported method(Ognyanov, V. I. et al., J. Med. Chem., 2006, 49, 3719-3742) was used to synthesize 2,3- dichloro-5-formylpyridine. A mixture of 5,6-dichloro-3-pyridinemethanol (1.42 g, 8.00 mmol) and Mn02 (13.9 g, 160 mmol) in 1 : 1 CH2Cl2/hexane (8 mL) was stirred for 1 h, then diluted with 50% EtOAc/hexane (20 mL), and filtered (50% EtOAc/hexane wash). The filtrate was evaporated, and the residue was dried in vacuo for use in the next step.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 54127-30-9, (5,6-Dichloropyridin-3-yl)methanol.
Reference:
Patent; WAYNE STATE UNIVERSITY; SANDFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; FONTANA, Joseph, A.; DAWSON, Marcia; XIA, Zebin; WO2011/79305; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem