Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54232-43-8, name is 6-Bromo-5-methoxypicolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 6-Bromo-5-methoxypicolinic acid
2-Bromo-3 -methoxy-6-pyridinecarboxylic acid 5-1 was prepared as previously described (Kelly, T. R. and Lang, F. J. Org. Chem., 1996, 61, 4623-4633). Compound 5-1 (1.000 g, 4.31 mmol) was dissolved in trifluoroacetic acid (24 mL) under inert atmosphere. Hydrogen peroxide, 30% aqueous solution (2.686 mL, 23.7 mmol) was added and the solution was heated to 80 C for 12.5 hr. After cooling, water (6 mL) was added and solvents were removed under reduced pressure. Additionalwater (10 mL) was added, the resulting suspension was triturated for 1 hr, whereupon the solids were filtered using a fritted funnel, washed with water (3 x 5 mL) and dried in vacuo to provide 2-bromo-3-methoxy-6-carboxypyridine-N-oxide 5-2 (0.827 g, 79.5%). ?H NIVIR (300 MHz, DMSO-d6): = 8.26 (d, 1H, ArH), 7.57 (d, 1H, ArH), 4.04 (s, 3H, OCH3). ?3C NMR (400 MFIz, D20/NaOD): = 167.5, 155.3, 142.0, 125.6, 121.6, 57.5.
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Reference:
Patent; LUMIPHORE, INC.; BUTLIN, Nathaniel G.; MAGDA, Darren; XU, Jide; (114 pag.)WO2016/106241; (2016); A1;,
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