Synthetic Route of 56826-61-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 56826-61-0 as follows.
(2-Methyl-pyridin-3-yl)-methanol (1.0 g, 8.13 mmol) was dissolved in dry CH2Cl2 (30 mL) and argon gas was purged for 10 min. Dess-Martin periodinane (4.5 g, 10.5 mmol) was added to the reaction mixture at 0 C, The reaction mixture was allowed to come to rt and further stirred for 2 h. The reaction mixture was quenched with saturated NaHCO3 solution. The organic product was extracted with EtOAc, The combined organic extracts were washed with saturated sodium thiosulfate solution, water and brine solution. Solvent was removed under reduced pressure to the crude 2-methylnicotinaldehyde (600 mg, crude), which was used as such for the next step. TLC: 100% EtOAc, Rf = 0.4. 1H NMR (300 MHz, CDCl3) delta 10.33 (s, 1H), 8.70-8.68 (dd, J = 4.8 Hz, 1.8 Hz, 1H), 8.12-8.09 (dd, J = 7.7 Hz, 1.8 Hz, 1H), 7.36-7.32 (dd, J = 7.7 Hz, 4.8 Hz, 1H), 2.89 (s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56826-61-0, its application will become more common.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19621; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem