Adding a certain compound to certain chemical reactions, such as: 582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 582303-10-4, blongs to pyridine-derivatives compound. Product Details of 582303-10-4
To a mixture of methyl (4- (difluoromethyl) -6-hydroxy-l- benzothiophen-3-yl) acetate (78 mg) and THF (dry) (2 mL) were added (2, 6-dimethylpyridin-3-yl) methanol (43.2 mg) , tri-n- butylphosphine (0.212 mL) and ADDP (94 mg) at room temperature. The mixture was stirred at room temperature for 2 h. To the mixture were added ADDP (94 mg) and tri-n-butylphosphine (0.212 mL) , and the mixture was stirred at room temperature for 30 min. The insoluble material was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by short pad of silica gel (EtOAc/hexane ) . To a mixture of the residue and THF (2 mL) was added IN NaOH (1 mL) at room temperature. The mixture was stirred at room temperature for 16 h. The mixture was neutralized with IN HCl at room temperature and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgS04 and concentrated in vacuo. The crude product was purified by preparative HPLC (C18, H20/CH3CN (including 10 mM NH4HC03) ) . The fraction was extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgS0 and concentrated in vacuo. The residue was crystallized from EtOAc-hexane to give the title compound (29.1 mg) .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,582303-10-4, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
Pyridine – Wikipedia,
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