Synthetic Route of 58584-92-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58584-92-2, name is 2-Amino-6-chloronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of (4-aminomethyl-phenyl)-phenylamine described in Preparation Example 20 (345mg, 1.74mmol) and 2-amino-6-chloro-nicotinic acid (300mg, 1.74mmol) in N,N-dimethylformamide (10mL) were benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (924mg, 2.09mmol) and triethylamine (0.49mL, 3.48mmol), and the solution was stirred overnight at room temperature. Ethyl acetate and water were added to the reaction solution, which was then partitioned, the organic layer was washed with water, and then, dried over anhydrous magnesium sulfate. The solvent was evaporated, the residue was purified by silica gel column chromatography (hexane : ethyl acetate), and the title compound (360mg, 59percent) was obtained as a pale yellow solid. 1H-NMR Spectrum (CDCl3) delta(ppm) : 4.51 (2H, d, J=5.2Hz), 5.74(1 H, s), 6.16(1H, brs), 6.57(1H, d, J=8.0Hz), 6.58(2H, s), 6.94-6.97(1 H, m), 7.04-7.09(4H, m), 7.21-7.30(4H, m), 7.52(1 H, d, J=8.0Hz).
According to the analysis of related databases, 58584-92-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
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