Extracurricular laboratory: Synthetic route of 5975-12-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5975-12-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 5975-12-2, 2,4-Dichloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5975-12-2, blongs to pyridine-derivatives compound. name: 2,4-Dichloro-3-nitropyridine

[00142] To a solution of 2,4-dichloro-3-nitropyridine (0.60 g, 3.1 mmol) in 10 mL of N,N-dimethylformamide was added potassium carbonate (0.64 g, 4.65 mmol) and tert-bvAyl 4-aminopiperidine-l-carboxylate (0.62 g, 3.1 mmol). Upon completion of addition, the reaction mixture was stirred at ambient temperature for 3 h. After this time, the reaction mixture was diluted with ethyl acetate, washed with IN HCl and brine, dried over MgSO4 and then concentrated to a yellow oil. The yellow oil was purified by flash chromatography on silica gel (elution with 1 : 1 EtOAc/hexane) to afford 0.65 g (59%) of Example IA as a yellow solid. 1H NMR (CDCl3): delta 8.01 (d, IH, J=6.1 Hz), 6.64 (d, IH, J=6.0 Hz), 6.48 (d, IH, J=6.5 Hz), 4.08-3.98 (m, 2H), 3.60-3.52 (m, IH), 3.00-2.90 (m, 2H), 2.05-1.95 (m, 2H), 1.50-1.42 (m, 2H), 1.44 (s, 9H). LRMS (ESI): 357.1/359.1 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5975-12-2, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/137436; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem